RoundCube Webmail is a browser-based multilingual IMAP client with an application-like user interface. It provides full functionality you expect from an e-mail client, including MIME support, address book, folder manipulation, message searching and spell checking. See screenshot from here.
RoundCube Webmail is written in PHP and requires a MySQL or Postgres database. The user interface is fully skinnable using XHTML and CSS 2.
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